Olanzapine (oh-LAN-za-peen, sold as Zyprexa®, Zydis®, or in combination with fluoxetine, as Symbyax®) was the second atypical antipsychotic to gain approval by the Food and Drug Administration (FDA) and has become one of the most commonly used atypical antipsychotics. Olanzapine has been approved by the FDA for the treatment of schizophrenia, acute mania in bipolar disorder, agitation associated with schizophrenia and bipolar disorder, and as maintenance treatment in bipolar disorder. It has also been established in treating depression off-label because of its mood-stabilizing properties and its ability to increase the efficacy of antidepressants. Olanzapine is manufactured and marketed by the pharmaceutical company Eli Lilly and Company. It is available as a pill that comes in the strengths of 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, and 20 mg and as as Zydis orally disintegrating tablets in the strengths of 5 mg, 10 mg, 15 mg, and 20 mg. It is also available as a rapid-acting intramuscular injection for short term acute use.

Case-reports, open-label, and small pilot studies suggest efficacy of olanzapine for the treatment of some anxiety spectrum disorders (e.g. general anxiety disorder, panic disorder, post-traumatic stress disorder); however, olanzapine has not been rigorously evaluated in randomized, placebo-controlled trials for this use and is not FDA approved for these indications. Other common off-label uses of olanzapine include the treatment of eating disorders (e.g. anorexia nervosa) and as an adjunctive treatment for major depressive disorder with psychotic features.

Pharmacology

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Olanzapine is structurally similar to clozapine, and is classified as a thienobenzodiazepine. Olanzapine has a high affinity for dopamine and serotonin receptors. Like most atypical antipsychotics compared to the older typical ones, Olanzapine has a lower affinity for histamine, cholinergic muscarinic and alpha adrenergic receptors. The mechanism of action of olanzapine is unknown, however it is theorized that olanzapine's antipsychotic activity is mediated primarily by antagonism at dopamine receptors, specifically D2. Serotonin antagonism may also play a role in the effectiveness of olanzapine, but the significance of 5-HT2A antagonism is debated among researchers. Antagonism at muscarinic, histaminic and alpha adrenergic receptors likely explains some of the side effects of olanzapine, such as anticholinergic effects, weight gain, sedation and orthostatic hypotension.

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Don't worry I can handle crazzy I've worked with Psych pts! Zyprexa! RT @DDubsBahamama2: @bellizzima they don't get any crazyer then me
bellizzima (bellizzima) Fri, 09 Oct 2009 01:35:45 -0000
Don't worry I can handle crazzy I've worked with Psych pts! Zyprexa! RT @DDubsBahamama2: @bellizzima they don't get any crazyer then me
em maio de 2010 termina a patente do Zyprexa... o difícil será ter de aguentar similares que não fazem efeito...
Leandrogavinier (LeandroGavinier) Fri, 09 Oct 2009 00:49:11 -0000
em maio de 2010 termina a patente do Zyprexa... o difícil será ter de aguentar similares que não fazem efeito...
Canada's Federal Court invalidated Eli Lilly’s Canadian Patent No. 2,041,113 for the compound olanzapine (Zyprexa).
Patent_Israel (Gil, LIVNE) Thu, 08 Oct 2009 21:03:06 -0000
Canada's Federal Court invalidated Eli Lilly’s Canadian Patent No. 2,041,113 for the compound olanzapine (Zyprexa).
Golytly UAD-Customer asked how to take it-His friend with him said "quit taking your Zyprexa and the vioce in your head will tell you how."
AshleyRPh (Ashley RPh) Thu, 08 Oct 2009 20:07:22 -0000
Golytly UAD-Customer asked how to take it-His friend with him said "quit taking your Zyprexa and the vioce in your head will tell you how."
having another Zyprexa hangover. syke!
ThatJayDee (Jay Dee Pritchard) Thu, 08 Oct 2009 17:53:35 -0000
having another Zyprexa hangover. syke!
Zyprexa[4 bipolar]this drug [not prescribed] was falsley chrgd to my friend Bob 4 times n 1 mo,the cost was.. http://bit.ly/2iBWy #p2
TheFakeJoeBiden (TheFakeJoeBiden) Thu, 08 Oct 2009 15:00:43 -0000
Zyprexa[4 bipolar]this drug [not prescribed] was falsley chrgd to my friend Bob 4 times n 1 mo,the cost was.. http://bit.ly/2iBWy #p2

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